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Algorithm for the diagnosis of the Factor V Leiden mutation and APC Resistance
*The most commonly used screening assay is PTT-based.
Some alternative screening assays are relatively insensitive to lupus anticoagulants
As hirudin or argatroban anticoagulation prolongs the PTT, a DNA test would be recommended if these anticoagulants are present
Algorithm for the diagnosis of the factor V Leiden mutation and activated protein C resistance.
Used with permission from Laposata and Van Cott.
Laposata M, Van Cott EM. How to work up hypercoagulability. CAP Today. 2000;14:24-26.
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